Endocrine Abstracts

The role of genetic factors in the pathogenesis of Graves’ disease (GD) is not clear. The purpose of this study was to investigate the association between single nucleotide polymorphisms in pro-inflammatory cytokine genes and GD in Iranian patients. A case–control hospitalbased study was carried out on 107 GD patients and 140 healthy controls. Cytokine typing was performed by PCR with sequence-specific primers (PCR-SSP) assay. The allele and genotype frequencies of t...

Background: Oxidized low-density lipoprotein (Ox-LDL) is a key factor in the development of arteriosclerosis. It can cause endothelial dysfunction and augment lipid accumulation within the arterial wall. Increased oxidative stress in diabetes contributes to this process. Ox-LDL is a highly immunogenic molecule and it is not clear whether oxidized LDL antibodies (OLAB) are pathogenic or protective in arteriosclerosis? The aim of this study was to evaluate Ox-LDL and its antibod...

This study aimed to compare the prevalence of metabolic syndrome (MetS) and its components in different degrees of obesity. A total of 2309 adults (aged 25–75 years) who were referred to a large university general hospital, divided into four groups according to their body mass index (BMI); 1511 subjects were non-obese (BMI<30 kg/m2); 535 subjects were moderate (30≤BMI<35); 176 subjects were severe (35≤BMI<40) and 87 subjects were very se...

The endothelial dysfunction and atherosclerosis. Recent studies have demonstrated that the amount of oxidized LDL (Ox-LDL) in plasma is correlated with IR in non-diabetic population. The intent of this study was to evaluate correlation of Ox-LDL and IR in diabetic patients, and to compare it with normal individuals.Methods: A total of 150 individuals aged 40 to 65 years were studied including 81 type 2 diabetic patients and 69 non-diabetic sex and BMI ma...

Aims/Introduction: To evaluate the impact of diabetes mellitus on the incidence of related micro- and macrovascular outcomes as well as cost analysis in people with type 2 diabetes mellitus.Materials and methods: In a cohort study, registered patients with type 2 diabetes mellitus were followed for 10 years at a tertiary care center. The type of medications and clinical data were extracted from patients’ archives. Incidence of mortality, micro- and ...

Background and aims: Due to increasing risk of hypoglycemia, tight control of glycemia is difficult to achieve in the diabetic patients with diabetic nephropathy. Also, there are no absolute guidelines defining appropriate dosing adjustments of insulin in such patients. This study was aimed to determine the safety and efficacy of insulin glargine in type 2 diabetic patients with diabetic nephropathy.Methods: A total of 89 subjects with type 2 diabetes (m...